This article by Peter Gutmann talks a lot about the DRM risks and limitations in Windows Vista (especially if you have SPDIF or component video), but several items mentioned are important to malware fighters as well, especially regarding future reverse-engineering issues.
Windows Vista includes an extensive reworking of core OS elements in order to provide content protection for so-called “premium content”, typically HD data from Blu-Ray and HD-DVD sources. Providing this protection incurs considerable costs in terms of system performance, system stability, technical support overhead, and hardware and software cost. These issues affect not only users of Vista but the entire PC industry, since the effects of the protection measures extend to cover all hardware and software that will ever come into contact with Vista, even if it’s not used directly with Vista (for example hardware in a Macintosh computer or on a Linux server). This document analyses the cost involved in Vista’s content protection, and the collateral damage that this incurs throughout the computer industry.